Frontiers in Cell and Developmental Biology (Mar 2021)

Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant Tumors

  • Kang Hu,
  • Qing-Kang Zheng,
  • Rui-Jie Ma,
  • Chao Ma,
  • Zhi-Gang Sun,
  • Nan Zhang

DOI
https://doi.org/10.3389/fcell.2021.661731
Journal volume & issue
Vol. 9

Abstract

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Krüppel-like factor 6 (KLF6) is one of the most studied members of the specificity protein/Krüppel-like factor (SP/KLF) transcription factor family. It has a typical zinc finger structure and plays a pivotal role in regulating the biological processes of cells. Recently, it has been considered to play a role in combatting cancer. Krüppel-like factor 6 splice variant 1 (KLF6-SV1), being one of the alternative KLF6 splicing isoforms, participates in tumor occurrence and development and has the potential to become a new target for molecular targeted therapy, although its action mechanism remains to be determined. The purpose of this article is to provide a comprehensive and systematic review of the important role of KLF6-SV1 in human malignant tumors to provide novel insights for oncotherapy.

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