PROTEASOMES AND EXOSOMES IN OVARIAN CANCER: RALATION WITH DISEASE PROGNOSIS AND CLINICAL OUTCOME

Abstract

The role of circulating proteasomes (C-proteasomes) representing a multisubunit complex with several proteolytically active sites, and exosomes, which are extracellular vesicles providing intracellular and interstitial transfer of biologically important molecules (proteins and miRNAs) in the pathogenesis of ovarian cancer, has been described. Currently, there are prerequisites for further study of the role of C-proteasome and exosome not only as prognostic markers, but also as predictors of the effectiveness of neoadjuvant chemotherapy and optimal cytoreduction.

Keywords

• circulating proteasomes
• exosomes
• ovarian cancer
• prognosis
• neoadjuvant chemotherapy