Bax protein as a prognostic marker in colorectal cancer: characteristics, role in apoptosis regulation, and correlation with disease prognosis (literature review)

Abstract

This review analyzes clinical significance of Bax biomarker in colorectal cancer. We cover the most important characteristics of this protein, describe its role in the apoptosis regulation mechanisms, and asses its prognostic value. Despite the fact that multiple studies have significantly improved our knowledge of Bax expression in colorectal cancer, its impact on the disease prognosis remains poorly understood. Many issue related to its correlation with clinical and morphological characteristics of the tumor still have to be clarified.

Keywords

• molecular biomarkers
• bax
• overexpression
• apoptosis
• colorectal cancer