6p21 translocation renal cell carcinoma: A case report

Yuho Sano; Ryuta Tanimoto; Katsumi Sasaki; Satoko Nakamura; Koichi Mizobuchi; Naoto Kuroda

Urology Case Reports (Jan 2021)

6p21 translocation renal cell carcinoma: A case report

Yuho Sano,
Ryuta Tanimoto,
Katsumi Sasaki,
Satoko Nakamura,
Koichi Mizobuchi,
Naoto Kuroda

Affiliations

Yuho Sano: Department of Urology, Kagawa Prefectural Central Hospital, Japan
Ryuta Tanimoto: Department of Urology, Kagawa Prefectural Central Hospital, Japan; Corresponding author.
Katsumi Sasaki: Department of Urology, Kagawa Prefectural Central Hospital, Japan
Satoko Nakamura: Department of Pathology, Kagawa Prefectural Central Hospital, Japan
Koichi Mizobuchi: Department of Pathology, Kagawa Prefectural Central Hospital, Japan
Naoto Kuroda: Department of Pathology, Konan Medical Center, USA

Journal volume & issue: Vol. 34
p. 101470

Abstract

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6p21 translocation renal cell carcinoma (RCC) was newly classified in the WHO 2016 classification as a subtype of microphthalmia-associated transcription factor (MIT) family translocation RCC.A 42-year-old man was referred to our hospital with an asymptomatic solid mass in the right kidney identified during routine medical checkup. Computed tomography (CT) revealed a 14-mm buried-type solid mass accompanied by punctate calcification. CT-guided biopsy suggested clear-cell carcinoma. He underwent robotic-assisted partial nephrectomy. Pathological findings revealed 6p21 translocation RCC based on diffuse nuclear immunoreactivity for TFEB and TFEB gene rearrangement in tumor cells by FISH analysis.

Published in Urology Case Reports

ISSN: 2214-4420 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: http://www.urologycasereports.com/

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Abstract

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