A 5-HT Antagonist (UP 26-91) versus Codeine and Placebo in a Human Experimental Pain Study

Lars Arendt-Nielsen; Poul Pedersen; Lars Poulsen; Ole Kæseler Andersen; Peter Bjerring; Isabelle Coste; Jorge Insuasty; Søren Sindrup; Asbjørn Mohr Drewes

doi:10.1155/2000/842198

Pain Research and Management (Jan 2000)

A 5-HT Antagonist (UP 26-91) versus Codeine and Placebo in a Human Experimental Pain Study

Lars Arendt-Nielsen,
Poul Pedersen,
Lars Poulsen,
Ole Kæseler Andersen,
Peter Bjerring,
Isabelle Coste,
Jorge Insuasty,
Søren Sindrup,
Asbjørn Mohr Drewes

Affiliations

Lars Arendt-Nielsen: Center for Sensory-Motor Interaction, Aalborg University, Aalborg, Denmark
Poul Pedersen: Department of Medicine, Aalborg Hospital, Aalborg, Denmark
Lars Poulsen: Department of Medicine, Aalborg Hospital, Aalborg, Denmark
Ole Kæseler Andersen: Center for Sensory-Motor Interaction, Aalborg University, Aalborg, Denmark
Peter Bjerring: Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark
Isabelle Coste: Department of Clinical Research, UPSA Laboratories, Rueil-Malmaison, France
Jorge Insuasty: Department of Clinical Research, UPSA Laboratories, Rueil-Malmaison, France
Søren Sindrup: Department of Clinical Pharmacology, Odense University, Odense, Denmark
Asbjørn Mohr Drewes: Center for Sensory-Motor Interaction, Aalborg University, Aalborg, Denmark

DOI: https://doi.org/10.1155/2000/842198
Journal volume & issue: Vol. 5, no. 2
pp. 135 – 140

Abstract

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BACKGROUND: This double-blind, randomized, crossover study compared the potential analgesic effect of the serotonin receptor antagonist UP 26-91 (50 mg, 150 mg and 300 mg) with that of codeine (100 mg) and placebo by use of different human experimental pain models.

Published in Pain Research and Management

ISSN: 1203-6765 (Print); 1918-1523 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General)
Website: https://www.hindawi.com/journals/prm/

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