Nature Communications (Jun 2022)

Asynchronous glutamate release is enhanced in low release efficacy synapses and dispersed across the active zone

  • Philipe R. F. Mendonça,
  • Erica Tagliatti,
  • Helen Langley,
  • Dimitrios Kotzadimitriou,
  • Criseida G. Zamora-Chimal,
  • Yulia Timofeeva,
  • Kirill E. Volynski

DOI
https://doi.org/10.1038/s41467-022-31070-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

Read online

Neurotransmitters can be released with a delay in relation to action potentials. This work demonstrates how this asynchronous release is related to overall vesicle release probability and short-term plasticity.