Association of baseline fasting plasma glucose with 1-year mortality in non-diabetic patients with acute cerebral infarction: a multicentre observational cohort study
Jing Wang,
Yan Wang,
Fang Wang,
Songdi Wu,
Huan Zhang,
Pei Liu,
Dandan Zhang,
Zhongzhong Liu,
Weiyan Guo,
Qingli Lu,
Congli Huang,
Qiaoqiao Chang,
Mi Zhang,
Yan Huo,
Xuemei Lin
Affiliations
Jing Wang
Xi`an Key Laboratory for Innovation and Translation of Neuroimmunological Diseases, Xi’an No.1 Hospital, Xi`an, Shaanxi, China
Yan Wang
Department of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi`an, Shaanxi, China
Fang Wang
Nursing Department, Zhejiang University School of Medicine, Women’s Hospital, Hangzhou, China
Songdi Wu
Department of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi`an, Shaanxi, China
Huan Zhang
Department of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi`an, Shaanxi, China
Pei Liu
Department of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi`an, Shaanxi, China
Dandan Zhang
Xi`an Key Laboratory for Innovation and Translation of Neuroimmunological Diseases, Xi’an No.1 Hospital, Xi`an, Shaanxi, China
Zhongzhong Liu
Department of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi`an, Shaanxi, China
Weiyan Guo
Department of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi`an, Shaanxi, China
Qingli Lu
Department of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi`an, Shaanxi, China
Congli Huang
Traditional Chinese Medicine, Xi’an No.1 Hospital, Xi`an, Shaanxi, China
Qiaoqiao Chang
Department of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi`an, Shaanxi, China
Mi Zhang
Department of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi`an, Shaanxi, China
Yan Huo
Department of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi`an, Shaanxi, China
Xuemei Lin
Department of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi`an, Shaanxi, China
Objectives Evidence on the association between fasting blood glucose and mortality in non-diabetic patients who had a stroke is limited. We aimed to investigate the association of baseline fasting plasma glucose (FPG) with 1 year all-cause mortality in non-diabetic patients with acute cerebral infarction (ACI).Design A multicentre prospective cohort study.Setting Four grade A tertiary hospitals in the Xi'an district of China.Participants A total of 1496 non-diabetic patients within 7 days of ACI were included.Main outcome measures The outcome was 1 year all-cause mortality. Baseline FPG was analysed as a continuous variable and was divided into four quartiles (group Q1–group Q4). We used multivariable Cox regression analyses, curve fitting and Kaplan–Meier (K-M) analyses to explore the association of baseline FPG with 1 year all-cause mortality in non-diabetic patients with ACI.Results After controlling for confounders, multivariable Cox regression analyses indicated a 17% increase in 1 year all-cause mortality for every 1 mmol/L of baseline FPG increase (HR=1.17, 95% CI 1.02 to 1.35, p=0.030). Patients from the Q4 group had 2.08 times increased hazard of 1 year all-cause mortality compared with the Q1 group (HR=2.08, 95% CI 1.13 to 3.82, p=0.019), while the survival rate of patients in group Q4 was decreased compared with that in other groups (p<0.001). The curve fitting revealed a positive but non-linear association of baseline FPG with 1-year all-cause mortality in non-diabetic patients with ACI.Conclusion In non-diabetic patients with ACI, elevated baseline FPG is an independent risk factor for 1-year all-cause mortality, and the two are positively and non-linearly associated. These results suggest that high FPG should be seen as a concern in non-diabetic patients with ACI.
