Comparison of Different Time Nutritional Intervention on Chemotherapy-induced Ⅳ Degree Myelosuppression in Cancer Patients

Abstract

Objective To explore and evaluate the effect of different time nutrition intervention on chemotherapy-induced Ⅳ degree myelosuppression in cancer patients. Methods A retrospective analysis was conducted on two groups of caner patients with chemotherapy-induced Ⅳ degree myelosuppression. The early nutritional intervention group: patients received nutritional intervention within 72 hours after diagnosis of Ⅳ degree myelosuppression; in contrast, the other group was set as the late nutrition intervention group. We investigated and compared the difference between the two groups in the rising time of leukocyte and platelet, bacterial infection rates, fungal infection rates and mortality rates. Results In the early nutritional intervention group, the rising time of leukocyte and platelet ((4.8±1.8) and (7.6±2.2)) was earlier than those in the late nutritional intervention group((7.2±2.5) and (12.2±3.1)); in addition, the early nutritional support group sustained significantly fewer incidence of bacterial infection, fungal infection and mortality(17.10%, 9.21% and 3.94%) than those in the late nutritional intervention group (42.85%, 26.98% and 12.70%). Conclusion The early nutritional intervention could reduce the recovery time of leukocyte and platelet, bacterial infection rates, fungal infection rates and mortality rates.

Keywords

• myelosuppression
• nutritional support
• comparative study
• chemotherapy