M6A modification of circNSUN2 promotes colorectal liver metastasis

Rong-Zhang He; Jing Jiang; Di-Xian Luo

Genes and Diseases (Jan 2021)

M6A modification of circNSUN2 promotes colorectal liver metastasis

Rong-Zhang He,
Jing Jiang,
Di-Xian Luo

Affiliations

Rong-Zhang He: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, PR China; Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, 423000, PR China; Corresponding author. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, PR China.
Jing Jiang: Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, 423000, PR China; Center for Clinical Pathology, The First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, 423000, PR China
Di-Xian Luo: Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, 423000, PR China; Center for Clinical Pathology, The First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, 423000, PR China; Corresponding author. Center for Clinical Pathology, The First People's Hospital of Chenzhou, University of South China, Chenzhou, 423000, PR China.

Journal volume & issue: Vol. 8, no. 1
pp. 6 – 7

Abstract

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Circular RNAs (circRNAs) are playing emerging role in the pathogenesis of cancers, but the mechanisms still unknown. In the recent issue of the Nature Communications, Chen and colleagues have demonstrated that YTHDC1 facilitates N6-methyladenosine modified circNSUN2 cytoplasmic export and the circNSUN2/IGF2BP2/HMGA2 complex stabilizes HMGA2 to promote colorectal liver metastasis. These discoveries not only expand our understanding of circRNAs biology in tumor, but also demonstrate that m6A modification plays a key role for circRNAs in RNA metabolism. Therefore, these findings indicate that circRNAs may be a new approach for therapeutic target of cancers.

Published in Genes and Diseases

ISSN: 2352-3042 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Medicine: Medicine (General); Science: Biology (General): Genetics
Website: https://www.keaipublishing.com/en/journals/genes-and-diseases/

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