Nature Communications (Mar 2019)
Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2
- Alberto Caminero,
- Justin L. McCarville,
- Heather J. Galipeau,
- Celine Deraison,
- Steve P. Bernier,
- Marco Constante,
- Corinne Rolland,
- Marlies Meisel,
- Joseph A. Murray,
- Xuechen B. Yu,
- Armin Alaedini,
- Brian K. Coombes,
- Premysl Bercik,
- Carolyn M. Southward,
- Wolfram Ruf,
- Bana Jabri,
- Fernando G. Chirdo,
- Javier Casqueiro,
- Michael G. Surette,
- Nathalie Vergnolle,
- Elena F. Verdu
Affiliations
- Alberto Caminero
- Farncombe Family Digestive Health Research Institute, McMaster University
- Justin L. McCarville
- Farncombe Family Digestive Health Research Institute, McMaster University
- Heather J. Galipeau
- Farncombe Family Digestive Health Research Institute, McMaster University
- Celine Deraison
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS
- Steve P. Bernier
- Farncombe Family Digestive Health Research Institute, McMaster University
- Marco Constante
- Farncombe Family Digestive Health Research Institute, McMaster University
- Corinne Rolland
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS
- Marlies Meisel
- Department of Medicine, University of Chicago
- Joseph A. Murray
- Division of Gastroenterology and Hepatology, Department of Immunology, Mayo Clinic College of Medicine
- Xuechen B. Yu
- Department of Medicine, Columbia University
- Armin Alaedini
- Department of Medicine, Columbia University
- Brian K. Coombes
- Department of Biochemistry and Biomedical Sciences, McMaster University
- Premysl Bercik
- Farncombe Family Digestive Health Research Institute, McMaster University
- Carolyn M. Southward
- Farncombe Family Digestive Health Research Institute, McMaster University
- Wolfram Ruf
- Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center
- Bana Jabri
- Department of Medicine, University of Chicago
- Fernando G. Chirdo
- Instituto de Estudios Inmunologicos y Fisiopatologicos - IIFP (UNLP-CONICET). Facultad de Ciencias Exactas, Universidad Nacional de La Plata
- Javier Casqueiro
- Department of Microbiology, Universidad de Leon
- Michael G. Surette
- Farncombe Family Digestive Health Research Institute, McMaster University
- Nathalie Vergnolle
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS
- Elena F. Verdu
- Farncombe Family Digestive Health Research Institute, McMaster University
- DOI
- https://doi.org/10.1038/s41467-019-09037-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Gluten triggers celiac disease in genetically predisposed individuals, but additional unknown mechanisms are required. Here, the authors show that proteases from Pseudomonas aeruginosa can modulate inflammatory pathways that are relevant to the development of food sensitivities, independently of the trigger antigen.
