Frontiers in Oncology (Nov 2021)

Case Report: Detection of Symptomatic Treatment-Related Changes in a Patient With Anaplastic Oligodendroglioma Using FET PET

  • Elena Katharina Bauer,
  • Jan-Michael Werner,
  • Gereon R. Fink,
  • Gereon R. Fink,
  • Karl-Josef Langen,
  • Karl-Josef Langen,
  • Karl-Josef Langen,
  • Norbert Galldiks,
  • Norbert Galldiks,
  • Norbert Galldiks

DOI
https://doi.org/10.3389/fonc.2021.735388
Journal volume & issue
Vol. 11

Abstract

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Following local and systemic treatment of gliomas, the differentiation between glioma relapse and treatment-related changes such as pseudoprogression or radiation necrosis using conventional MRI is limited. To overcome this limitation, various amino acid PET tracers such as O-[2-(18F)-fluoroethyl]-L-tyrosine (FET) are increasingly used and provide valuable additional clinical information. We here report neuroimaging findings in a clincally symptomatic 53-year-old woman with a recurrent anaplastic oligodendroglioma with MRI findings highly suspicious for tumor progression. In contrast, FET PET imaging suggested treatment-related changes considerably earlier than the regression of contrast enhancement on MRI. In patients with oligodendroglioma, the phenomenon of symptomatic treatment-related changes is not well described, making these imaging findings unique and important for clinical decision-making.

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