Antioxidants (Mar 2023)

Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease

  • Swetha Pavani Rao,
  • Prakashkumar Dobariya,
  • Harshini Bellamkonda,
  • Swati S. More

DOI
https://doi.org/10.3390/antiox12030603
Journal volume & issue
Vol. 12, no. 3
p. 603

Abstract

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3-mercaptopyruvate sulfurtransferase (3-MST) plays the important role of producing hydrogen sulfide. Conserved from bacteria to Mammalia, this enzyme is localized in mitochondria as well as the cytoplasm. 3-MST mediates the reaction of 3-mercaptopyruvate with dihydrolipoic acid and thioredoxin to produce hydrogen sulfide. Hydrogen sulfide is also produced through cystathionine beta-synthase and cystathionine gamma-lyase, along with 3-MST, and is known to alleviate a variety of illnesses such as cancer, heart disease, and neurological conditions. The importance of cystathionine beta-synthase and cystathionine gamma-lyase in hydrogen sulfide biogenesis is well-described, but documentation of the 3-MST pathway is limited. This account compiles the current state of knowledge about the role of 3-MST in physiology and pathology. Attempts at targeting the 3-MST pathway for therapeutic benefit are discussed, highlighting the potential of 3-MST as a therapeutic target.

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