Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing

Kishor K. Sivaraj; Paul-Georg Majev; Hyun-Woo Jeong; Backialakshmi Dharmalingam; Dagmar Zeuschner; Silke Schröder; M. Gabriele Bixel; Melanie Timmen; Richard Stange; Ralf H. Adams

doi:10.1038/s41467-022-28142-w

Nature Communications (Jan 2022)

Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing

Kishor K. Sivaraj,
Paul-Georg Majev,
Hyun-Woo Jeong,
Backialakshmi Dharmalingam,
Dagmar Zeuschner,
Silke Schröder,
M. Gabriele Bixel,
Melanie Timmen,
Richard Stange,
Ralf H. Adams

Affiliations

Kishor K. Sivaraj: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine
Paul-Georg Majev: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine
Hyun-Woo Jeong: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine
Backialakshmi Dharmalingam: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine
Dagmar Zeuschner: Electron Microscopy Unit, Max-Planck-Institute for Molecular Biomedicine
Silke Schröder: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine
M. Gabriele Bixel: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine
Melanie Timmen: Department of Regenerative Musculoskeletal Medicine, Institute of Musculoskeletal Medicine (IMM), University Hospital Münster
Richard Stange: Department of Regenerative Musculoskeletal Medicine, Institute of Musculoskeletal Medicine (IMM), University Hospital Münster
Ralf H. Adams: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine

DOI: https://doi.org/10.1038/s41467-022-28142-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Developmental and regenerative bone formation require the removal of chondrocytes and matrix. Here the authors show that these processes involve mesenchymal stromal cell-derived septoclasts, which disappear after the completion of development but re-emerge during fracture healing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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