Replication confers β cell immaturity

Sapna Puri; Nilotpal Roy; Holger A. Russ; Laura Leonhardt; Esra K. French; Ritu Roy; Henrik Bengtsson; Donald K. Scott; Andrew F. Stewart; Matthias Hebrok

doi:10.1038/s41467-018-02939-0

Nature Communications (Feb 2018)

Replication confers β cell immaturity

Sapna Puri,
Nilotpal Roy,
Holger A. Russ,
Laura Leonhardt,
Esra K. French,
Ritu Roy,
Henrik Bengtsson,
Donald K. Scott,
Andrew F. Stewart,
Matthias Hebrok

Affiliations

Sapna Puri: Diabetes Center, Department of Medicine, University of California
Nilotpal Roy: Diabetes Center, Department of Medicine, University of California
Holger A. Russ: Diabetes Center, Department of Medicine, University of California
Laura Leonhardt: Diabetes Center, Department of Medicine, University of California
Esra K. French: Department of Endocrinology, Diabetes and Metabolism, University of Pittsburgh
Ritu Roy: Helen Diller Family Comprehensive Cancer Center, University of California
Henrik Bengtsson: Helen Diller Family Comprehensive Cancer Center, University of California
Donald K. Scott: Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai
Andrew F. Stewart: Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai
Matthias Hebrok: Diabetes Center, Department of Medicine, University of California

DOI: https://doi.org/10.1038/s41467-018-02939-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Adult beta cells, which are highly specialised insulin-secreting cells, rarely replicate. Puri et al. demonstrate that beta cell proliferative capacity is inversely correlated with their functionality and differentiation state, by inducing proliferation of adult cells with ectopic overexpression of the cell cycle regulator c-Myc.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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