Nature Communications (Feb 2018)

Replication confers β cell immaturity

  • Sapna Puri,
  • Nilotpal Roy,
  • Holger A. Russ,
  • Laura Leonhardt,
  • Esra K. French,
  • Ritu Roy,
  • Henrik Bengtsson,
  • Donald K. Scott,
  • Andrew F. Stewart,
  • Matthias Hebrok

DOI
https://doi.org/10.1038/s41467-018-02939-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Adult beta cells, which are highly specialised insulin-secreting cells, rarely replicate. Puri et al. demonstrate that beta cell proliferative capacity is inversely correlated with their functionality and differentiation state, by inducing proliferation of adult cells with ectopic overexpression of the cell cycle regulator c-Myc.