Perbandingan Kadar Mikroalbuminuria Pada Stroke Infark Aterotrombotik Dengan Faktor Risiko Hipertensi dan Pasien Hipertensi

Abstract

Microalbuminuria is a marker of vascular damage in glomerular system caused by vascular risk factors : hypertension, diabetes mellitus, lipid profile, smoking, older age, genetic and atherosclerosis. Microalbuminuria is a window of vasculature damage in cerebrovascular system. Correlation between microalbuminuria and cerebrovascular disease is not well established. This was an observational analytical case control study, conducted on December 2007 to July 2008 in Hasan Sadikin Hospital Bandung. Measurement of microalbuminuria level was done in case group (35 subjects atherotrombotic infarction stroke with hypertension as the risk factor) and control group (35 subjects with hypertension). Comparison of microalbuminuria level were analyzed with independent T test. Determinant factor for atherotrombotic infarction stroke incidence was analyzed with multiple regression logistic. Mean rate of microalbuminuria level in case group was higher (54.76 mg/24 hours) compared with control (23.56 mg/24 hours) and comparison was significant (p=0.013). Multiple logistic regression analyzed that microalbuminuria as an independent determinant factor for atherotrombotic infarction stroke in patients with hypertension (p=0.032, OR=2.91, CI95%). Patients with hypertension and microalbuminuria had an increased risk for atherotrombotic infarction stroke 2,91 times than hypertension without microalbuminuria. Microalbuminuria level suggested as a routine examination in patients with hypertension for primary prevention of atherotrombotic infarction stroke.

Keywords

• Atherotrombotic infarction stroke
• hypertension
• microalbuminuria