Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction

Sarah McLaughlin; Brian McNeill; James Podrebarac; Katsuhiro Hosoyama; Veronika Sedlakova; Gregory Cron; David Smyth; Richard Seymour; Keshav Goel; Wenbin Liang; Katey J. Rayner; Marc Ruel; Erik J. Suuronen; Emilio I. Alarcon

doi:10.1038/s41467-019-12748-8

Nature Communications (Oct 2019)

Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction

Sarah McLaughlin,
Brian McNeill,
James Podrebarac,
Katsuhiro Hosoyama,
Veronika Sedlakova,
Gregory Cron,
David Smyth,
Richard Seymour,
Keshav Goel,
Wenbin Liang,
Katey J. Rayner,
Marc Ruel,
Erik J. Suuronen,
Emilio I. Alarcon

Affiliations

Sarah McLaughlin: BioEngineering and Therapeutic Solutions (BEaTS), Division of Cardiac Surgery, University of Ottawa Heart Institute
Brian McNeill: BioEngineering and Therapeutic Solutions (BEaTS), Division of Cardiac Surgery, University of Ottawa Heart Institute
James Podrebarac: BioEngineering and Therapeutic Solutions (BEaTS), Division of Cardiac Surgery, University of Ottawa Heart Institute
Katsuhiro Hosoyama: BioEngineering and Therapeutic Solutions (BEaTS), Division of Cardiac Surgery, University of Ottawa Heart Institute
Veronika Sedlakova: BioEngineering and Therapeutic Solutions (BEaTS), Division of Cardiac Surgery, University of Ottawa Heart Institute
Gregory Cron: Department of Radiology, Faculty of Medicine, University of Ottawa
David Smyth: Cardiac Function Laboratory, University of Ottawa Heart Institute
Richard Seymour: BioEngineering and Therapeutic Solutions (BEaTS), Division of Cardiac Surgery, University of Ottawa Heart Institute
Keshav Goel: BioEngineering and Therapeutic Solutions (BEaTS), Division of Cardiac Surgery, University of Ottawa Heart Institute
Wenbin Liang: Department of Cellular & Molecular Medicine, University of Ottawa
Katey J. Rayner: Cardiometabolic microRNA Laboratory, University of Ottawa Heart Institute
Marc Ruel: BioEngineering and Therapeutic Solutions (BEaTS), Division of Cardiac Surgery, University of Ottawa Heart Institute
Erik J. Suuronen: BioEngineering and Therapeutic Solutions (BEaTS), Division of Cardiac Surgery, University of Ottawa Heart Institute
Emilio I. Alarcon: BioEngineering and Therapeutic Solutions (BEaTS), Division of Cardiac Surgery, University of Ottawa Heart Institute

DOI: https://doi.org/10.1038/s41467-019-12748-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Many patients, following therapy for acute myocardial infarction, develop adverse cardiac remodelling. Here the authors present injectable recombinant human collagen 10 of 10 type I and III matrices that are able to limit adverse remodelling and improve function of the myocardium.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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