npj Breast Cancer (Jul 2017)

Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion

  • Dillon G. Patterson,
  • Justin T. Roberts,
  • Valeria M. King,
  • Dominika Houserova,
  • Emmaline C. Barnhill,
  • Aline Crucello,
  • Caroline J. Polska,
  • Lucas W. Brantley,
  • Garrett C. Kaufman,
  • Michael Nguyen,
  • Megann W. Santana,
  • Ian A. Schiller,
  • Julius S. Spicciani,
  • Anastasia K. Zapata,
  • Molly M. Miller,
  • Timothy D. Sherman,
  • Ruixia Ma,
  • Hongyou Zhao,
  • Ritu Arora,
  • Alexander B. Coley,
  • Melody M. Zeidan,
  • Ming Tan,
  • Yaguang Xi,
  • Glen M. Borchert

DOI
https://doi.org/10.1038/s41523-017-0032-8
Journal volume & issue
Vol. 3, no. 1
pp. 1 – 12

Abstract

Read online

RNA: Small nucleolar-derived RNA contributes to tumor invasiveness A short microRNA-like fragment excised from a small nucleolar RNA (called a snoRNA-derived RNA or sdRNA) contributes to the invasiveness of breast cancer cells. Glen Borchert from the University of South Alabama, USA, and colleagues compared the expression of sdRNAs between a primary breast cancer cell line and a metastatic one. They identified 13 sdRNAs with markedly different abundances. Blocking the sdRNA with the biggest expression differential sdRNA-93-decreased cellular invasion, whereas increasing its abundance enhanced tumor cell invasiveness. Looking at human tissues, sdRNA-93 was routinely expressed in biopsies taken from patients with the luminal HER2-positive form of breast cancer, less often in other tumor types and almost never in healthy breast samples. Hinting at its function, the researchers showed that sdRNA-93 targets and regulates a gene contributing to specific molecular subtypes of breast cancer.