The causes of dysregulation of immune response in pulmonary tuberculosis: the role of disorders of the initial state of immunological reactivity of the organism

Abstract

Genetically determinate and acquired disorders of immune reactivity in tuberculosis infection are discussed in this review. The changes in immunocompetent cells, manifested in a disorder of the structure of their cell membranes, proliferation processes, intracellular metabolism and functional activity, which cause reduced resistance of the organism to infection with Mycobacterium tuberculosis and contribute to the formation of secondary immunological deficiency in pulmonary tuberculosis are described.

Keywords

• туберкулез легких
• иммунологическая реактивность
• вторичная иммунологическая недостаточность
• иммунокомпетентные клетки
• полиморфизм генов