Anti-osteoporotic effects and good biocompatibility of novel bioactive carbon quantum dots in vitro and in ovariectomized mice
Talante Juma,
Guang-Hua Liang,
Yang Jiao,
Yuan-Yuan Ma,
Bing-Xiao Yu,
Yi-Min Guo,
Xin Yang,
Heng Liu,
Zhi-Chao Meng,
Rui Wang,
Hao Wu,
Li-Ping Pan,
Hao Wang,
Ya-Hong Wang,
Yong-Ping Cao,
Tao Zhang
Affiliations
Talante Juma
Orthopaedic Department, Peking University First Hospital, Beijing 100034, China
Guang-Hua Liang
Orthopaedic Department, Peking University First Hospital, Beijing 100034, China
Yang Jiao
Orthopaedic Department, Peking University First Hospital, Beijing 100034, China
Yuan-Yuan Ma
Animal Experiment Center, Peking University First Hospital, Beijing 100034, China
Bing-Xiao Yu
Orthopaedic Department, Peking University First Hospital, Beijing 100034, China
Yi-Min Guo
ChinaSchool of Materials Science and Engineering, Beihang University, Beijing 100191, China
Xin Yang
Orthopaedic Department, Peking University First Hospital, Beijing 100034, China
Heng Liu
Orthopaedic Department, Peking University First Hospital, Beijing 100034, China
Zhi-Chao Meng
Orthopaedic Department, Peking University First Hospital, Beijing 100034, China
Rui Wang
Orthopaedic Department, Peking University First Hospital, Beijing 100034, China
Hao Wu
Orthopaedic Department, Peking University First Hospital, Beijing 100034, China
Li-Ping Pan
Orthopaedic Department, Peking University First Hospital, Beijing 100034, China
Hao Wang
Orthopaedic Department, Peking University First Hospital, Beijing 100034, China
Ya-Hong Wang
Harbin Chengcheng Institute for Material and Life, Harbin 150500, China
Yong-Ping Cao
Orthopaedic Department, Peking University First Hospital, Beijing 100034, China; Corresponding author
Tao Zhang
ChinaSchool of Materials Science and Engineering, Beihang University, Beijing 100191, China; Harbin Chengcheng Institute for Material and Life, Harbin 150500, China; Corresponding author
Summary: Osteoporosis is a prevalent condition among the elderly, and current treatments are limited by their side effects. This study aimed to develop a safe nanocarbon material with anti-osteoporotic properties. A promising candidate, carbon quantum dots (CQDs), was synthesized using a single-step liquid-phase pulse method and characterized by transmission electron microscopy (TEM). To evaluate the biocompatibility and anti-osteoporotic effects of CQDs, they were administered at a dose of 276 μg/mL or a placebo to an osteoporotic mouse model (n = 16) for 3 months. Biocompatibility was assessed through monitoring weight changes, general health, blood tests, and H&E staining of visceral organs. To assess bone quality, imaging, histological analysis, and biomechanical tests were performed. The results showed that CQDs significantly inhibited osteoclastic activity, leading to improved bone mass and mechanical strength without obvious toxicity. These findings suggest CQDs as a promising candidate for safer osteoporosis therapies.
