ATHEROGENIC NORMOLIPIDEMIA IN MEN WITH CORONARY ATHEROSCLEROSIS: SOME PECULIARITIES OF SUBFRACTIONAL DISTRIBUTION OF APO B-CONTAINING LIPOPROTEINS

Abstract

Background: Plasma apo B-containing lipoproteins of low densities represent a heterogeneous population of particles varying by physicochemical composition, functional activity, and atherogenicity. Aim: To study some peculiarities in low density lipoproteins subfractional distribution in men with coronary atherosclerosis at normolipidemia. Material and methods: Patients with angiographically documented coronary atherosclerosis were included into the study ( n = 177; mean age 62.5 ± 9.3 yrs). Lipoprotein subfractional distribution was analyzed using Lipoprint LDL System (Quantimetrix, USA). Results: Out the total cohort normolipidemic patients (total C < 5,0 mmol/l, TG < 1.7 mmol/l, LDL-C < 2.5 mmol/l) with coronary atherosclerosis were selected and thereafter were split into those without small dense LDL (sdLDL) - group 1, n = 16, and and group 2 with presence of sdLDL ( n = 22). Patients from group 2 had lower portion of IDLB: 7.0 ± 1.2 vs 8.5 ± 1.0 %, IDLА: 7.9 ± 1.7 vs 9.6 ± 2.5 %, and higher LDL2 portion: 7.0 ± 2.0 vs 4.3 ± 1.6 %. In group 2 C level in LDL2 was higher than in group 1 while in IDL B it appeared to be lower. Mean LDL particles size in group 2 was lower as well: 270.7 ± 1.3 и 273.8 ± 0.8 Е. Conclusion. In men with coronary atherosclerosis at normolipidemia two different patterns of subfractional distribution of apo B-containing lipoproteins were detected. Presence of sd LDL associated with decreased LDL size could be regarded as more atherogenic profile even at normal lipid levels.

Keywords

• coronary atherosclerosis
• normolipidemia
• subfractional profile
• lipoprint ldl system