Comparative efficacy of different therapeutic schemes in gastropathies provoked by nonsteroid anti-inflammatory drugs

Abstract

Aim. To study efficacy of colloid bismuth subcitrate (de-nol, Yamanuchi) in therapy of gastropathies provoked by nonsteroidal anti-inflammatory drugs (NSAID). Material and methods. 63 patients (38 women and 25 men, mean age 54.2 ± 12.8 years) with rheumatoid arthritis (n = 14), osteoarthrosis (n = 47), gouty arthritis (n = 2) regularly taking NSAID were examined. The patients were randomized into two groups. The patients of the control group 1 received therapy with omeprasol (40 mg/day), patients of group 2 were given omeprasol (40 mg/day) and de-nol (480 mg/day). Results. Epithelization of erosive-ulcerous lesions were observed on the treatment day 28 in 93.9% patients of group 1 and all the patients of group 2. Normalization of the level of prostaglandin E, by the end of the treatment was registered in 57% and 93.3% patients of groups 1 and 2, respectively. Conclusion. Colloid bismuth subcitrate (de-nol) effectively improves the condition of NSAID gastropathy patients, stimulates healing of erosive-ulcerous lesions of gastroduodenal zone in elevation of prostaglandins levels.

Keywords

• nonsteroid anti-inflammatory drugs
• gastric ulcer
• gastropathies provoked by nonsteroid antiinflammatory drugs
• prostaglandins
• de-nol