Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL

Timothy S.E. Albert; Philippe N. Duchateau; Samir S. Deeb; Clive R. Pullinger; Min H. Cho; David C. Heilbron; Mary J. Malloy; John P. Kane; B. Greg Brown

Journal of Lipid Research (Mar 2005)

Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL

Timothy S.E. Albert,
Philippe N. Duchateau,
Samir S. Deeb,
Clive R. Pullinger,
Min H. Cho,
David C. Heilbron,
Mary J. Malloy,
John P. Kane,
B. Greg Brown

Affiliations

Timothy S.E. Albert: Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA; Department of Cardiovascular Research Institute, University of California, San Francisco, CA
Philippe N. Duchateau: Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA; Department of Cardiovascular Research Institute, University of California, San Francisco, CA
Samir S. Deeb: Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA; Department of Cardiovascular Research Institute, University of California, San Francisco, CA
Clive R. Pullinger: Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA; Department of Cardiovascular Research Institute, University of California, San Francisco, CA
Min H. Cho: Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA; Department of Cardiovascular Research Institute, University of California, San Francisco, CA
David C. Heilbron: Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA; Department of Cardiovascular Research Institute, University of California, San Francisco, CA
Mary J. Malloy: Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA; Department of Cardiovascular Research Institute, University of California, San Francisco, CA
John P. Kane: Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA; Department of Cardiovascular Research Institute, University of California, San Francisco, CA
B. Greg Brown: Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA; Department of Cardiovascular Research Institute, University of California, San Francisco, CA

Journal volume & issue: Vol. 46, no. 3
pp. 469 – 474

Abstract

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Apolipoprotein L-I (apoL-I) is present on a subset of HDL particles and is positively correlated with plasma triglycerides (TGs). We measured plasma apoL-I levels in coronary artery disease (CAD) subjects with low HDL who were enrolled in an angiographic CAD prevention trial. At baseline, apoL-I levels (n = 136; range, 2.2–64.1 μg/ml) were right skewed with a large degree of variability. Multivariate analysis for biological determinants of apoL-I revealed that the log of VLDL-TG (+0.17; P 50% higher than normoglycemic subjects (n = 112; 13.2 vs. 8.3 μg/ml, respectively; P 50% (n = 36; P < 0.01). Genotyping of a known apoL-I polymorphism (Lys166Glu) did not independently account for any of the variability in apoL-I levels.In conclusion, we found TG and HG to be the strongest predictors of apoL-I within a dyslipidemic CAD population. These data provide further characterization of the novel HDL-associated apoL-I.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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