Nature Communications (Oct 2020)

Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence

  • Andrea Walens,
  • Jiaxing Lin,
  • Jeffrey S. Damrauer,
  • Brock McKinney,
  • Ryan Lupo,
  • Rachel Newcomb,
  • Douglas B. Fox,
  • Nathaniel W. Mabe,
  • Jeremy Gresham,
  • Zhecheng Sheng,
  • Alexander B. Sibley,
  • Tristan De Buysscher,
  • Hemant Kelkar,
  • Piotr A. Mieczkowski,
  • Kouros Owzar,
  • James V. Alvarez

DOI
https://doi.org/10.1038/s41467-020-18730-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

Read online

The cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them to study the clonal dynamics of tumor recurrence.