Nature Communications (Nov 2016)
Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer
- Christine Henzler,
- Yingming Li,
- Rendong Yang,
- Terri McBride,
- Yeung Ho,
- Cynthia Sprenger,
- Gang Liu,
- Ilsa Coleman,
- Bryce Lakely,
- Rui Li,
- Shihong Ma,
- Sean R. Landman,
- Vipin Kumar,
- Tae Hyun Hwang,
- Ganesh V. Raj,
- Celestia S. Higano,
- Colm Morrissey,
- Peter S. Nelson,
- Stephen R. Plymate,
- Scott M. Dehm
Affiliations
- Christine Henzler
- Minnesota Supercomputing Institute, University of Minnesota
- Yingming Li
- Masonic Cancer Center, University of Minnesota
- Rendong Yang
- Minnesota Supercomputing Institute, University of Minnesota
- Terri McBride
- Masonic Cancer Center, University of Minnesota
- Yeung Ho
- Masonic Cancer Center, University of Minnesota
- Cynthia Sprenger
- Division of Gerontology and Geriatric Medicine, University of Washington
- Gang Liu
- Division of Gerontology and Geriatric Medicine, University of Washington
- Ilsa Coleman
- Fred Hutchinson Cancer Research Center
- Bryce Lakely
- Department of Urology, University of Washington
- Rui Li
- Department of Urology, University of Texas Southwestern Medical Center
- Shihong Ma
- Department of Urology, University of Texas Southwestern Medical Center
- Sean R. Landman
- Department of Computer Science and Engineering, University of Minnesota
- Vipin Kumar
- Department of Computer Science and Engineering, University of Minnesota
- Tae Hyun Hwang
- Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center
- Ganesh V. Raj
- Department of Urology, University of Texas Southwestern Medical Center
- Celestia S. Higano
- Fred Hutchinson Cancer Research Center
- Colm Morrissey
- Department of Urology, University of Washington
- Peter S. Nelson
- Fred Hutchinson Cancer Research Center
- Stephen R. Plymate
- Division of Gerontology and Geriatric Medicine, University of Washington
- Scott M. Dehm
- Masonic Cancer Center, University of Minnesota
- DOI
- https://doi.org/10.1038/ncomms13668
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
Castration-resistant prostate cancer frequently presents with persistent androgen receptor signalling. Here, the authors find that the androgen receptor is subject to genetic rearrangements, resulting in variants with ligand-independent activity.
