Nature Communications (Apr 2018)

Theoretical principles of transcription factor traffic on folded chromatin

  • Ruggero Cortini,
  • Guillaume J. Filion

DOI
https://doi.org/10.1038/s41467-018-04130-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

Read online

How transcription factors find their targets in vivo is still poorly understood. Here the authors use molecular dynamics simulations to investigate how transcription factors diffuse on chromatin, providing a theoretical framework for understanding the key role of genome conformation in this process.