Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection

Teding Chang; Jingzhi Yang; Hai Deng; Deng Chen; XiangPing Yang; Zhao-Hui Tang

doi:10.3389/fimmu.2022.843342

Frontiers in Immunology (Feb 2022)

Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection

Teding Chang,
Jingzhi Yang,
Hai Deng,
Deng Chen,
XiangPing Yang,
Zhao-Hui Tang

Affiliations

Teding Chang: Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji Hospital, Tongji, China
Jingzhi Yang: Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji Hospital, Tongji, China
Hai Deng: Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji Hospital, Tongji, China
Deng Chen: Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji Hospital, Tongji, China
XiangPing Yang: Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Zhao-Hui Tang: Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji Hospital, Tongji, China

DOI: https://doi.org/10.3389/fimmu.2022.843342
Journal volume & issue: Vol. 13

Abstract

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Uncontrolled severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 infection is closely related to disorders of the innate immune and delayed adaptive immune systems. Dendritic cells (DCs) “bridge” innate immunity and adaptive immunity. DCs have important roles in defending against SARS-CoV-2 infection. In this review, we summarize the latest research concerning the role of DCs in SARS-CoV-2 infection. We focus on the complex interplay between DCs and SARS-CoV-2: pyroptosis-induced activation; activation of the renin–angiotensin–aldosterone system; and activation of dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin. We also discuss the decline in DC number, the impaired antigen-presentation capability, and the reduced production of type-I interferon of DCs in severe SARS-CoV-2 infection. In addition, we discuss the potential mechanisms for pathological activation of DCs to understand the pattern of SARS-CoV-2 infection. Lastly, we provide a brief overview of novel vaccination and immunotherapy strategies based on DC targeting to overcome SARS-CoV-2 infection.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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