Cancer Management and Research (Oct 2022)

Survival Outcomes of Complete Pulmonary Metastasectomy for Head and Neck Squamous Cell Carcinomas

  • Kuroda H,
  • Koyama S,
  • Mun M,
  • Nakajima J,
  • Funai K,
  • Yoshino I,
  • Yamauchi Y,
  • Kawamura M

Journal volume & issue
Vol. Volume 14
pp. 3095 – 3103

Abstract

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Hiroaki Kuroda,1 Shin Koyama,1 Mingyon Mun,2 Jun Nakajima,3 Kazuhito Funai,4 Ichiro Yoshino,5 Yoshikane Yamauchi,6 Masafumi Kawamura6 On behalf of the Metastatic Lung Tumor Study Group of Japan1Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan; 2Department of Thoracic Surgical Oncology, Cancer Institute Hospital Japanese Foundation for Cancer Research, Tokyo, Japan; 3Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan; 4First Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan; 5Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan; 6Department of Surgery, Teikyo University School of Medicine, Tokyo, JapanCorrespondence: Hiroaki Kuroda, Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1-1, Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan, Tel +81-52-762-6111, Fax +81-52-763-5233, Email [email protected]: Metastatic head and neck squamous cell carcinoma (HNSCC) is relatively poor; however, depending on the selected cases, pulmonary metastasectomy can be a practical therapeutic option. This study aimed to identify the outcomes of complete metastasectomy based on each primary site and to investigate unfavorable prognostic factors.Patients and Methods: We used the database from the Metastatic Lung Tumour Study Group of Japan. Between November 1980 and April 2017, 231 patients were deemed eligible. According to anatomy and the current epidemiology of HNSCC, the patients were divided into three groups: nasopharynx, oropharynx, and salivary gland (n = 40, Group 1), oral cavity, tongue, and paranasal sinuses (n = 69, Group 2), and larynx and hypopharynx (n = 122, Group 3).Results: The 5-year overall survival after complete pulmonary metastasectomy was 58.5%, 25.0%, and 46.9% in G1, 2, and 3, respectively (p 20 mm. Therefore, on dividing group 1 and 3 with or without diameter, the 5-year overall survival was significantly worse in HNSCC with a diameter > 20 mm (n = 74) than that in the remnant (n = 88; 61.9% vs 35.5%; p 20 mm) were poor prognostic factors for pulmonary metastasectomy from head and neck cancer.Keywords: pulmonary metastasectomy, head and neck squamous cell carcinoma, pulmonary metastasis, survival outcomes

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