IDENTIFIKASI POTENSI INTERAKSI OBAT PADA PASIEN RAWAT INAP PENYAKIT DALAM DI RSUD Prof. Dr. MARGONO SOEKARJO PURWOKERTO DENGAN METODE OBSERVASIONAL RETROSPEKTIF PERIODE NOVEMBER 2009-JANUARI 2010

Abstract

The potensial drug interaction is potential action of a drug that changed or influced by other drugs concurrenly. Drug interactions are defined as a phenomenon that occurs when the pharmacokinetic effect of a drug changes due to other drug delivery. Drug interactions could cause advers drug reactions when the potential for a previously unknown interaction. The purpose of this study is to identify potential drug interactions in patient hospitalized in the Prof. Dr. Margono Soekarjo Purwokerto Hospital. The research method was an observasional retrospective study (November 2009-January 2010) by using descriptive methods for the data analysis.The result showed that the potential drug interactions in the hospitalized patients in Prof. Dr. Margono Soekarjo Hospital is 56,76% (n= 259). Based on the significance categories which proposed by Tatro (2006): a potential drug interaction with significance category 1 in ward patients in prof. Dr. Margono Soekarjo Hospital is 16,67%. The drug used thet known potential interaction, especially in the category of significance 1 should be tailored to the patient’s need, risk and benefit, and have made efforts to optimize it.

Keywords

• Potensial drug interaction
• advers drug reaction
• significance categories