Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers

Susana Llanos; Juana M. García-Pedrero; Lucia Morgado-Palacin; Juan P. Rodrigo; Manuel Serrano

doi:10.1038/ncomms10438

Nature Communications (Feb 2016)

Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers

Susana Llanos,
Juana M. García-Pedrero,
Lucia Morgado-Palacin,
Juan P. Rodrigo,
Manuel Serrano

Affiliations

Susana Llanos: Department of Molecular Oncology, Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO)
Juana M. García-Pedrero: Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo
Lucia Morgado-Palacin: Department of Molecular Oncology, Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO)
Juan P. Rodrigo: Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo
Manuel Serrano: Department of Molecular Oncology, Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO)

DOI: https://doi.org/10.1038/ncomms10438
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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The molecular pathways involving p21 and mTORC1 are frequently deregulated in head and neck squamous cell carcinomas (HNSCC). Here, Llanos et al. report a mechanism that regulates p21 stability through the mTORC1/4E-BP1 pathway independently of p53, and show that the mechanism is prevalent in HNSCC.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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