(<i>E</i>)-1-(3-Benzoyl-4-phenyl-1<i>H</i>-pyrrol-1-yl)-3-phenylprop-2-en-1-one

Abstract

Over the last decade, there has been an increasing effort to fight inflammatory conditions establishing new multitarget approaches. Chronic inflammation is implicated in many multifactorial diseases, constituting a great economic burden and a chronic health problem. In an attempt to develop new potent multifunctional anti-inflammatory agents, a cinnamic-pyrrole hybrid (6) was synthesized and screened for its antioxidant and anti-Lipoxygenase potential. The new compound, in comparison with its pyrrole precursor (4), showed improved biological activities. In silico calculations were performed to predict its drug-likeness. The examined derivative is considered orally bioavailable according to Lipinski’s rule of five. Compound 6 could be used as a lead for the synthesis of more effective hybrids.

Keywords

• inflammation
• hybrids
• cinnamic acid
• pyrroles
• antioxidant activity
• LOX