Barrier function and microbiotic dysbiosis in atopic dermatitis

Abstract

Sophie Seite,1 Thomas Bieber2 1La Roche-Posay Dermatological Laboratories, Asnières, France; 2Department of Dermatology and Allergy, Friedrich-Wilhelms-University, Bonn, GermanyAbstract: Atopic dermatitis (AD) or atopic eczema is the common inflammatory skin disorder, the prevalence of which has considerably increased during the last 30 years. It affects 15%–30% of children and 2%–10% of adults. AD characteristically alternates between periods of exacerbation or flares and periods of remission, which may be therapeutically induced or spontaneous. Current knowledge about AD includes abnormalities of the skin barrier (physical and chemical), the immune barrier, and more recently, the microbial barrier or microbiota. There is growing evidence for a tight relationship between them. To obtain satisfactory control of this condition, the clinical strategy to manage AD involves prescribing both anti-inflammatory medications and dermocosmetic products. The role of the physician is therefore to advise the patient with regard to hygiene measures aimed to help to improve these three barriers or to prevent any further deterioration. Keywords: atopic dermatitis, eczema, skin barrier, microbiome, immunity, dermocosmetic