How stroke-related dysphagia relates to quality of life: the mediating role of nutritional status and psychological disorders, and the moderating effect of enteral nutrition mode

Hongji Zeng; Xi Zeng; Nana Xiong; Nana Xiong; Nana Xiong; Lichun Wang; Ying Yang; Liugen Wang; Heping Li; Weijia Zhao

doi:10.3389/fnut.2024.1339694

Frontiers in Nutrition (Mar 2024)

How stroke-related dysphagia relates to quality of life: the mediating role of nutritional status and psychological disorders, and the moderating effect of enteral nutrition mode

Hongji Zeng,
Xi Zeng,
Nana Xiong,
Nana Xiong,
Nana Xiong,
Lichun Wang,
Ying Yang,
Liugen Wang,
Heping Li,
Weijia Zhao

Affiliations

Hongji Zeng: School of Public Health, Zhengzhou University, Zhengzhou, China
Xi Zeng: Department of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Nana Xiong: Peking University Sixth Hospital, Beijing, China
Nana Xiong: NHC Key Laboratory of Mental Health (Peking University), Beijing, China
Nana Xiong: National Clinical Research Centre for Mental Disorders (Peking University Sixth Hospital), Beijing, China
Lichun Wang: Cangzhou Hospital of Integrated Chinese and Western Medicine, Hebei, Cangzhou, China
Ying Yang: Department of Rehabilitation Medicine, The People’s Hospital of Suzhou New District, Suzhou, China
Liugen Wang: Department of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Heping Li: Department of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Weijia Zhao: School of Public Health, Zhengzhou University, Zhengzhou, China

DOI: https://doi.org/10.3389/fnut.2024.1339694
Journal volume & issue: Vol. 11

Abstract

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BackgroundAlthough stroke-related dysphagia has been shown to influence quality of life (QOL), the underlying mechanisms have yet to be uncovered.ObjectiveThis study aims to investigate the mediating role of nutritional status and psychological disorders in the relationship between stroke-related dysphagia and QOL in stroke patients and explore the moderating effect of enteral nutrition mode.MethodsIn 2022, A questionnaire survey using stratified random sampling was conducted on 5,322 stroke patients with dysphagia, including Functional Oral Intake Scale (FOIS), Swallowing Quality of Life Questionnaire, Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder-7 (GAD-7) to assess dysphagia, QOL and psychological disorders, respectively, for each participant. Records of serum albumin, Hemoglobin, Total serum protein, serum prealbumin and Body mass index were enrolled to assess nutritional status.ResultsFOIS demonstrated a significant positive predictive effect on QOL. Nutritional status and psychological disorders (PHQ-9 and GAD-7) mediated the relationship between FOIS and QOL. Nutritional status-psychological disorders showed a chain mediation effect in the relationship between FOIS and QOL. The moderating effect of enteral nutrition mode was observed.ConclusionThe mediating role of nutritional status and psychological disorders with moderating effect of enteral nutrition mode in the relationship between dysphagia and QOL in stroke patients was found.

Published in Frontiers in Nutrition

ISSN: 2296-861X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.frontiersin.org/journals/nutrition/

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