Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination

Margaret M. C. Lam; Kelly L. Wyres; Sebastian Duchêne; Ryan R. Wick; Louise M. Judd; Yunn-Hwen Gan; Chu-Han Hoh; Sophia Archuleta; James S. Molton; Shirin Kalimuddin; Tse Hsien Koh; Virginie Passet; Sylvain Brisse; Kathryn E. Holt

doi:10.1038/s41467-018-05114-7

Nature Communications (Jul 2018)

Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination

Margaret M. C. Lam,
Kelly L. Wyres,
Sebastian Duchêne,
Ryan R. Wick,
Louise M. Judd,
Yunn-Hwen Gan,
Chu-Han Hoh,
Sophia Archuleta,
James S. Molton,
Shirin Kalimuddin,
Tse Hsien Koh,
Virginie Passet,
Sylvain Brisse,
Kathryn E. Holt

Affiliations

Margaret M. C. Lam: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Kelly L. Wyres: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Sebastian Duchêne: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Ryan R. Wick: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Louise M. Judd: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Yunn-Hwen Gan: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
Chu-Han Hoh: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
Sophia Archuleta: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
James S. Molton: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
Shirin Kalimuddin: Department of Infectious Diseases, Singapore General Hospital
Tse Hsien Koh: Department of Microbiology, Singapore General Hospital
Virginie Passet: Institut Pasteur, Biodiversity and Epidemiology of Bacterial Pathogens
Sylvain Brisse: Institut Pasteur, Biodiversity and Epidemiology of Bacterial Pathogens
Kathryn E. Holt: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne

DOI: https://doi.org/10.1038/s41467-018-05114-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Since the 1980s, hypervirulent clonal-group CG23 serotype K1 Klebsiella pneumoniae has been recognised as a prominent cause of community-acquired liver abscess and other severe infections. Here, the authors investigate the genomic evolutionary history of CG23 and suggest a new reference strain for CG23.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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