International Journal of General Medicine (Jun 2021)

Association of Cardiac Troponin T Concentration on Admission with Prognosis in Critically Ill Patients without Myocardial Infarction: A Cohort Study

  • Xie R,
  • Chen Q,
  • He W,
  • Zeng M

Journal volume & issue
Vol. Volume 14
pp. 2729 – 2739

Abstract

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Ruijie Xie,* Qingui Chen,* Wanmei He, Mian Zeng Department of Medical Intensive Care Unit, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mian ZengDepartment of Medical Intensive Care Unit, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Road 2, Guangzhou, Guangdong, 510080, People’s Republic of ChinaTel +86-20-87755766Email [email protected]: To investigate the association of cardiac Troponin T (cTnT) with prognosis in critically ill patients without myocardial infarction.Methods: Adult patients admitted to the intensive care units (ICUs) of the Beth Israel Deaconess Medical Center between 2008 and 2019 who were free of myocardial infarction with a length of ICU stay ≥ 24 hours and available cTnT records within 24 hours before and after ICU admission were included. The association between cTnT on ICU admission and hospital mortality was evaluated by multivariable logistic regression analysis. The discrimination capacity of cTnT on ICU admission for predicting hospital mortality was examined by receiver operating characteristic (ROC) analysis.Results: A total of 2960 patients were included. Elevated cTnT (> 0.01 ng/mL) was observed in 2730 (92.23%) patients with a higher hospital mortality compared to normal cTnT (11.21% versus 7.39%, P=0.075). There was no statistically significant association between elevated cTnT on ICU admission and hospital mortality (adjusted odds ratio 1.50, 95% confidence interval (CI) 0.88– 2.57). Poor discrimination capacity was found for cTnT on ICU admission to predict hospital mortality (area under the ROC curve 0.48, 95% CI 0.44– 0.53).Conclusion: cTnT on ICU admission has limited prognostic value in critically ill patients without myocardial infarction.Keywords: cardiac troponin T, prognosis, critical care

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