BMC Psychiatry (Mar 2025)

The impact of cognitive behavioral therapy on disease uncertainty, stressful life events, quality of life, anxiety, and depression in glioma patients undergoing chemotherapy: a quasi-experimental study

  • Xiaonan Liu,
  • Xiaolei Qi,
  • Dandong Fang,
  • Shubing Feng,
  • Jing Chen,
  • Xue Li,
  • Jiajia Dang,
  • Lin Wu

DOI
https://doi.org/10.1186/s12888-025-06709-3
Journal volume & issue
Vol. 25, no. 1
pp. 1 – 9

Abstract

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Abstract Objective To investigate the effect of cognitive behavioral therapy on disease uncertainty and stressful life events in glioma patients undergoing chemotherapy. Methods This quasi-experimental study enrolled 90 glioma patients from Sanmenxia Central Hospital between January and December 2021. Patients were divided into an intervention group (n = 45) or a control group (n = 45). The intervention group received cognitive behavioral therapy provided by nurses, while the control group received routine nursing care. Pre- and post-intervention assessments were conducted using the Mishel uncertainty in illness scale (MUIS), life events scale (LES), self-rating anxiety scale (SAS), self-rating depression scale (SDS), and quality of life scale (WHOQOL-BREF). Results After four cycles of chemotherapy, the study group demonstrated a statistically significant decrease in MUIS and LES scores compared to the control group (p < 0.05). The study group showed significantly lower SAS and SDS scores than the control group (p < 0.05). Finally, the study group reported significantly higher WHOQOL-BREF scores than the control group (p < 0.05). Conclusion The study revealed that the group that received CBT showed significant improvements in the psychological well-being of glioma patients undergoing chemotherapy. These findings suggest that incorporating CBT into standard nursing care can effectively improve the psychological well-being and quality of life of glioma patients during chemotherapy.

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