Nature Communications (Mar 2017)

PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription

  • Hui Liang,
  • Xi Chen,
  • Qi Yin,
  • Danhui Ruan,
  • Xuyang Zhao,
  • Cong Zhang,
  • Michael A. McNutt,
  • Yuxin Yin

DOI
https://doi.org/10.1038/ncomms14771
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

PTEN is a potent tumour suppressor involved in cell growth, proliferation and survival. Here the authors identify an N-terminal extended isoform of PTEN, termed PTENβ that negatively regulates ribosomal DNA transcription and cell proliferation, expanding the pleiotropic functions of the PTEN family.