Nature Communications (Mar 2017)
PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription
Abstract
PTEN is a potent tumour suppressor involved in cell growth, proliferation and survival. Here the authors identify an N-terminal extended isoform of PTEN, termed PTENβ that negatively regulates ribosomal DNA transcription and cell proliferation, expanding the pleiotropic functions of the PTEN family.