MedEdPORTAL (Oct 2009)
Immunology Team-Based Learning: Innate Immunity & Recognition of Antigen
Abstract
Abstract Introduction This module on innate immunity and recognition of antigen is one of three developed for second-year biomedical science MS and PhD students enrolled in a semester-long immunology graduate course titled Principles in Immunology. Topics covered by the remaining modules include basic concepts of immunology and receptor diversity and antigen presentation. Methods This module uses a team-based learning format (TBL) to help learners understand the following immunological principles and how to apply them in experimental settings: function and pathways for activation of complement, effector mechanisms of innate immunity, antibody structure, T-cell receptor structure, major histocompatibility complex, molecule structure, and the molecular basis of antigen recognition by immunoglobulin and T-cell receptors. Students arrive at class having read preassigned readings. They first complete an individual Readiness Assurance Test, before completing the same test in groups. Students then remain in these groups while they complete a series of group application exercises. Results Student satisfaction with TBL is very high, as assessed by course evaluations over the past 3 years. Students say that TBL helps them keep up with material and prepare for exams. Student performance on high-stakes exams has revealed modest improvements in overall scores. Student performance in a graduate-level immunology course did not drop after implementation of TBL, which involved replacing nine of 42 lectures throughout the semester with TBL sessions. Graduate students enjoy TBL, and learning appears to be enhanced. Discussion Originally developed for second-year biomedical science MS and PhD students enrolled in a semester-long immunology graduate course, this material is also appropriate for basic science courses for medical and dental students and/or for review of immunology by residents and fellows.
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