Frontiers in Pharmacology (Nov 2021)
Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats
- Lei Sun,
- Lei Sun,
- Lei Sun,
- Minjuan Zhu,
- Minjuan Zhu,
- Minjuan Zhu,
- Jingfei Shi,
- Jingfei Shi,
- Jingfei Shi,
- Kun Mi,
- Kun Mi,
- Wenjing Ma,
- Wenjing Ma,
- Wenjing Ma,
- Xiangyue Xu,
- Xiangyue Xu,
- Xiangyue Xu,
- Hanyu Wang,
- Hanyu Wang,
- Hanyu Wang,
- Yuanhu Pan,
- Yuanhu Pan,
- Yuanhu Pan,
- Yanfei Tao,
- Yanfei Tao,
- Yanfei Tao,
- Zhenli Liu,
- Zhenli Liu,
- Zhenli Liu,
- Lingli Huang,
- Lingli Huang,
- Lingli Huang
Affiliations
- Lei Sun
- MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China
- Lei Sun
- National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, China
- Lei Sun
- College of Veterinary Medicine of Huazhong Agricultural University, Wuhan, China
- Minjuan Zhu
- MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China
- Minjuan Zhu
- National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, China
- Minjuan Zhu
- College of Veterinary Medicine of Huazhong Agricultural University, Wuhan, China
- Jingfei Shi
- MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China
- Jingfei Shi
- National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, China
- Jingfei Shi
- College of Veterinary Medicine of Huazhong Agricultural University, Wuhan, China
- Kun Mi
- MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China
- Kun Mi
- National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, China
- Wenjing Ma
- MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China
- Wenjing Ma
- National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, China
- Wenjing Ma
- College of Veterinary Medicine of Huazhong Agricultural University, Wuhan, China
- Xiangyue Xu
- MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China
- Xiangyue Xu
- National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, China
- Xiangyue Xu
- College of Veterinary Medicine of Huazhong Agricultural University, Wuhan, China
- Hanyu Wang
- MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China
- Hanyu Wang
- National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, China
- Hanyu Wang
- College of Veterinary Medicine of Huazhong Agricultural University, Wuhan, China
- Yuanhu Pan
- MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China
- Yuanhu Pan
- National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, China
- Yuanhu Pan
- College of Veterinary Medicine of Huazhong Agricultural University, Wuhan, China
- Yanfei Tao
- MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China
- Yanfei Tao
- National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, China
- Yanfei Tao
- College of Veterinary Medicine of Huazhong Agricultural University, Wuhan, China
- Zhenli Liu
- MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China
- Zhenli Liu
- National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, China
- Zhenli Liu
- College of Veterinary Medicine of Huazhong Agricultural University, Wuhan, China
- Lingli Huang
- MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China
- Lingli Huang
- National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, China
- Lingli Huang
- College of Veterinary Medicine of Huazhong Agricultural University, Wuhan, China
- DOI
- https://doi.org/10.3389/fphar.2021.754876
- Journal volume & issue
-
Vol. 12
Abstract
Illegal use of salbutamol (SAL), a β-adrenergic leanness-enhancing agent, has posed potential threat to human health in China. The excretion and depletion of SAL in pigs and goats were investigated, and the concentration correlations between edible tissues and living samples were analyzed to find out a suitable living sample for pre-slaughter monitoring of SAL in pigs and goats. After a single oral dosage of 1.2 mg/kg SAL, approximately 70% of the dose was excreted by pigs and goats from their excreta. When pigs and goats were supplied feed containing SAL (20 mg/kg) for 14 consecutive days, high concentrations of SAL were observed in the liver and kidneys, and the longest persistence was observed in hair. Unlike pigs, SAL was presented primarily as conjugated SAL in goats. Excellent concentration correlations of SAL were observed between urine and edible tissues both in pigs and goats, and in addition, good correlations also were found between hair and edible tissues in pigs and between feces and edible tissues in goats. Hence, urine and hair could accurately predict SAL concentrations in edible tissues of pigs, whereas feces and urine were satisfactory for predicting SAL concentrations in edible tissues of goats. These data make it possible for pre-slaughter monitoring of SAL residues in the edible tissues of pigs and goats.
Keywords
