Synthesis, Crystal Structure, Hirshfeld Surface Analysis, and Computational Approach of a New Pyrazolo[3,4‑g]isoquinoline Derivative as Potent against Leucine-Rich Repeat Kinase 2 (LRRK2)

• Etify A. Bakhite,
• Shaaban Kamel Mohamed,
• Chin-Hung Lai,
• Karthikeyan Subramani,
• Islam S. Marae,
• Suzan Abuelhassan,
• Abdelhamid A. E. Soliman,
• Mohamed S. K. Youssef,
• Hatem A. Abuelizz,
• Joel T. Mague,
• Rashad Al-Salahi,
• Youness El Bakri

Affiliations

Etify A. Bakhite

Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt

Shaaban Kamel Mohamed

Chemistry and Environmental Division, Manchester Metropolitan University, Manchester, England

Chin-Hung Lai

Department of Medical Applied Chemistry, Chung Shan Medical University, Taichung, Taiwan

Karthikeyan Subramani

Center for Healthcare Advancement, Innovation and Research, Vellore Institute of Technology University, Chennai Campus, Chennai, India

Islam S. Marae

Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt

Suzan Abuelhassan

Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt

Abdelhamid A. E. Soliman

Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt

Mohamed S. K. Youssef

Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt

Hatem A. Abuelizz

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Joel T. Mague

Department of Chemistry, Tulane University, New Orleans, Louisiana, United States

Rashad Al-Salahi

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Youness El Bakri

Department of Theoretical and Applied Chemistry, South Ural State University, Chelyabinsk, Russian Federation