PERUBAHAN POLA KADAR INTERLEUKIN-1β, FUNGSI FAGOSITOSIS DAN STATUS PERIODONTIUM PADA PENYANDANG DIABETES MELITUS TIPE 2

Abstract

Hyperglycemia, which occurs in type 2 diabetic patients increases prostaglandin E2 (PGE2), cytokine expression, and decreases neutrophil phagocytic function. This will induce inflammation and periodontal tissue destruction, thus decreasing periodontal status. The aim of the study was to analyze the pattern alteration of interleukin-1β (IL-1β) level, phagocytic function, and periodontal status. The study’s design was cross-sectional on 45 controlled diabetes mellitus (CDM) and 45 uncontrolled diabetes mellitus (UCDM) subjects and 45 non diabetic subjects, 40-60 years old in Metabolic-Endocrinology Clinic Cipto Mangunkusumo Hospital. Statistical analysis was performed using a Stata 7.0 software computer. The result showed that the pattern alteration of increasing IL-1β level was in 2 hours-post prandial glucose level of >150 mg/dL, decreasing phagocytic function in glucose level of >170 mg/dL, and decreasing periodontal status in flucose level of >240 mg/dL. Therefore it is concluded that the pattern alteration of decreasing periodontal status, increasing IL-1β, and decreasing phagocytic function showed on certain blood glucose levels.

Keywords

• Pattern of IL-1β level
• phagocytic function
• periodontal status type 2 DM patients