520 Preliminary biomarker and pharmacodynamic (PD) activity of the TGFβ inhibitor SAR439459, alone or in combination with cemiplimab, in a phase 1 clinical study in patients with advanced solid tumors

• Rui Wang,
• Ivan Borbath,
• Patrícia Martin,
• Armando Santoro,
• Bernard Doger,
• Elena Garralda,
• Oliver Bechter,
• Giovanni Abbadessa,
• Debbie Robbrecht,
• Grob Jean-Jacques,
• Butler Marcus,
• Cheng Tina,
• Bennouna Jaafar,
• Massimo Di Nicola,
• Alejo Rodriguez -Vida,
• Dirk Schadendof,
• Brigitte Demers,
• Amele Amrate,
• Tun Tun Lin,
• Manisha Brahmachary,
• Joon Sange Lee,
• Joachim Theilhaber,
• Rob Pomponio

Affiliations

Rui Wang

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China

Ivan Borbath

2 Université catholique de Louvain, IREC, Brussels, Belgium

Patrícia Martin

2Department of Biological and Biomedical Sciences, School of Health and Life Sciences, Glasgow Caledonian University

Armando Santoro

Medical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy

Bernard Doger

5Fundacion Jimenez Díaz, Madrid, Spain

Elena Garralda

6Vall d’Hebron Institute of Oncology, Barcelona, Spain

Oliver Bechter

1University Hospitals Leuven, Leuven, Belgium

Giovanni Abbadessa

1Sanofi, Cambridge, USA

Debbie Robbrecht

1Erasmus Medical Centre, Rotterdam, Netherlands

Grob Jean-Jacques

2APHM – Hopital de la Timone, Marseille, France

Butler Marcus

7Princess Margaret Hospital, NA, Canada

Cheng Tina

8Tom Baker Cancer Centre, NA, Canada

Bennouna Jaafar

10CHU de Nantes – Hotel Dieu, NA, France

Massimo Di Nicola

11Istituto Nazionale dei Tumori, NA, Italy

Alejo Rodriguez -Vida

14Hospital Del Mar, NA, Spain

Dirk Schadendof

15Universitatsklinikum Essen, NA, Germany

Brigitte Demers

17Sanofi, Cambridge, MA, USA

Amele Amrate

17Sanofi, Cambridge, MA, USA

Tun Tun Lin

17Sanofi, Cambridge, MA, USA

Manisha Brahmachary

17Sanofi, Cambridge, MA, USA

Joon Sange Lee

17Sanofi, Cambridge, MA, USA

Joachim Theilhaber

17Sanofi, Cambridge, MA, USA

Rob Pomponio

17Sanofi, Cambridge, MA, USA