A three-component synthesis of functionalized ketenimines by the reaction of alkyl isocyanides and dialkyl acetylenedicarboxylates in the presence of 2-quinolinol

Abstract

The 1:1 reactive intermediates generated by the addition of alkyl isocyanides to dialkyl acetylenedicarboxylates were trapped by 2-quinolinol to yield highly functionalized ketenimines and, in some cases, minor amounts of 1-azabuta-1,3-dienes.

Keywords

• ketenimines
• 1-azadienes
• alkyl isocyanides
• acetylenic esters
• NH-acids
• multi-component reaction