PLoS ONE (Jan 2019)

Development and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit.

  • Fiorenza Ferrari,
  • Mariangela Valentina Puci,
  • Ottavia Eleonora Ferraro,
  • Gregorio Romero-González,
  • Faeq Husain-Syed,
  • Lilia Rizo-Topete,
  • Mara Senzolo,
  • Anna Lorenzin,
  • Eva Muraro,
  • Antonio Baracca,
  • Mara Serrano-Soto,
  • Alejandra Molano Triviño,
  • Ana Coutinho Castro,
  • Massimo De Cal,
  • Valentina Corradi,
  • Alessandra Brendolan,
  • Marta Scarpa,
  • Maria Rosa Carta,
  • Davide Giavarina,
  • Raffaele Bonato,
  • Giorgio Antonio Iotti,
  • Claudio Ronco

DOI
https://doi.org/10.1371/journal.pone.0217424
Journal volume & issue
Vol. 14, no. 6
p. e0217424

Abstract

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AKI is associated with increased risk of death, prolonged length of stay and development of de-novo chronic kidney disease. The aim of our study is the development and validation of prediction models to identify the risk of AKI in ICU patients up to 7 days. We retrospectively recruited 692 consecutive patients admitted to the ICU at San Bortolo Hospital (Vicenza, Italy) from 1 June 2016 to 31 March 2017: 455 patients were treated as the derivation group and 237 as the validation group. Candidate variables were selected based on a literature review and expert opinion. Admission eGFR< 90 ml/min /1.73 mq (OR 2.78; 95% CI 1.78-4.35; p<0.001); SOFAcv ≥ 2 (OR 2.23; 95% CI 1.48-3.37; p<0.001); lactate ≥ 2 mmol/L (OR 1.81; 95% CI 1.19-2.74; p = 0.005) and (TIMP-2)•(IGFBP7) ≥ 0.3 (OR 1.65; 95% CI 1.08-2.52; p = 0.019) were significantly associated with AKI. For the q-AKI score, we stratified patients into different AKI Risk score levels: 0-2; 3-4; 5-6; 7-8 and 9-10. In both cohorts, we observed that the proportion of AKI patients was higher in the higher score levels.