Nature Communications (May 2017)
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand
- Xianjun Zhang,
- Fei Zhao,
- Yiran Wu,
- Jun Yang,
- Gye Won Han,
- Suwen Zhao,
- Andrii Ishchenko,
- Lintao Ye,
- Xi Lin,
- Kang Ding,
- Venkatasubramanian Dharmarajan,
- Patrick R. Griffin,
- Cornelius Gati,
- Garrett Nelson,
- Mark S. Hunter,
- Michael A. Hanson,
- Vadim Cherezov,
- Raymond C. Stevens,
- Wenfu Tan,
- Houchao Tao,
- Fei Xu
Affiliations
- Xianjun Zhang
- iHuman Institute, ShanghaiTech University
- Fei Zhao
- iHuman Institute, ShanghaiTech University
- Yiran Wu
- iHuman Institute, ShanghaiTech University
- Jun Yang
- Department of Pharmacology, School of Pharmacy, Fudan University
- Gye Won Han
- Departments of Chemistry, Biological Sciences and Physics & Astronomy, Bridge Institute, University of Southern California
- Suwen Zhao
- iHuman Institute, ShanghaiTech University
- Andrii Ishchenko
- Departments of Chemistry, Biological Sciences and Physics & Astronomy, Bridge Institute, University of Southern California
- Lintao Ye
- iHuman Institute, ShanghaiTech University
- Xi Lin
- iHuman Institute, ShanghaiTech University
- Kang Ding
- iHuman Institute, ShanghaiTech University
- Venkatasubramanian Dharmarajan
- Department of Molecular Therapeutics, The Scripps Research Institute
- Patrick R. Griffin
- Department of Molecular Therapeutics, The Scripps Research Institute
- Cornelius Gati
- Medical Research Council, Laboratory of Molecular Biology
- Garrett Nelson
- Department of Physics, Arizona State University
- Mark S. Hunter
- Linac Coherent Light Source, SLAC National Accelerator Laboratory
- Michael A. Hanson
- GPCR Consortium
- Vadim Cherezov
- Departments of Chemistry, Biological Sciences and Physics & Astronomy, Bridge Institute, University of Southern California
- Raymond C. Stevens
- iHuman Institute, ShanghaiTech University
- Wenfu Tan
- Department of Pharmacology, School of Pharmacy, Fudan University
- Houchao Tao
- iHuman Institute, ShanghaiTech University
- Fei Xu
- iHuman Institute, ShanghaiTech University
- DOI
- https://doi.org/10.1038/ncomms15383
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Smoothened receptors (SMO) play a key role in the Hedgehog signalling pathway. Here the authors present the structure of a multi-domain human SMO with a rationally designed stabilizing ligand bound in the transmembrane domain of the receptor, and propose a model for SMO activation.
