Nephrology Service, Hospital Clínic-IDIBAPS, Barcelona, Spain; Correspondence to: Department of Nephrology and Renal Transplantation, Hospital Clinic Barcelona, 170 Villarroel Street, Barcelona 08036, Spain.
Pablo Ruiz
Liver Unit, Hospital Clínic, IDIBAPS, CIBERehd, Barcelona, Spain
Herpes virus infections is not uncommon in solid organ transplantation patients. We report 3 cases with primary Herpes simplex virus type-1 (HSV1) infection with acute liver failure (ALF). This is a rare and potentially fatal entity that could be a donor-derived infection. Although the initial clinical presentation is non-specific, it should be considered as a differential diagnosis in HSV-negative serology patients with liver failure and empirical treatment must be started in combination with a drastic reduction of immunosuppression. A strategy of HSV prophylaxis for pre-transplant HSV seronegative patients must be stablished in order to reduce the risk of clinical disease.
