Postmortem Detection of “Clinically Undiagnosed” Diffuse Large B-Cell Lymphoma: Gross and Microscopic Findings
Vincenzo Cianci,
Daniela Sapienza,
Giovanni Bartoloni,
Alessio Cianci,
Annalisa Cracò,
Fausto Omero,
Patrizia Gualniera,
Alessio Asmundo,
Cristina Mondello
Affiliations
Vincenzo Cianci
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Legal Medicine, University of Messina, via Consolare Valeria 1, 98125 Messina, Italy
Daniela Sapienza
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Legal Medicine, University of Messina, via Consolare Valeria 1, 98125 Messina, Italy
Giovanni Bartoloni
Department of Anatomy, Diagnostic Pathology, Legal Medicine Hygiene and Public Health, University of Catania, 95122 Catania, Italy
Alessio Cianci
Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy
Annalisa Cracò
Department of Biomedical Sciences and Morphological and Functional Imaging, Diagnostic and Interventional Radiology Unit, University Hospital Messina, 98125 Messina, Italy
Fausto Omero
Medical Oncology Unit, Department of Human Pathology “G. Barresi”, University of Messina, 98125 Messina, Italy
Patrizia Gualniera
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Legal Medicine, University of Messina, via Consolare Valeria 1, 98125 Messina, Italy
Alessio Asmundo
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Legal Medicine, University of Messina, via Consolare Valeria 1, 98125 Messina, Italy
Cristina Mondello
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Legal Medicine, University of Messina, via Consolare Valeria 1, 98125 Messina, Italy
Diffuse large B-cell lymphoma is considered the most found non-Hodgkin lymphoma in adults. Diffuse large B-cell lymphoma, which also occurs in sporadic forms, is associated with some pathological conditions, including human immunodeficiency virus infection, especially if it progresses to AIDS. The authors report the case of a 45-year-old man with AIDS in whom a postmortem diagnosis of diffuse large B-cell lymphoma was performed. The proposed images document extensive pluri-visceral involvement, already visible macroscopically, and subsequently confirmed through histological examination.
