AIDS Research and Therapy (Jan 2024)

Effect of dolutegravir-based versus efavirenz-based antiretroviral therapy on excessive weight gain in adult treatment-naïve HIV patients at Matsanjeni health center, Eswatini: a retrospective cohort study

  • Didier M. Mukuna,
  • Tom Decroo,
  • Clara M. Nyapokoto

DOI
https://doi.org/10.1186/s12981-023-00591-3
Journal volume & issue
Vol. 21, no. 1
pp. 1 – 5

Abstract

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Abstract Background There is limited data on dolutegravir (DTG)-associated weight gain from settings with a dual burden of HIV and overnutrition. Methods In Eswatini (at Matsanjeni), among 156 and 160 adult patients on DTG-based and EFV-based antiretroviral therapy (ART), respectively, we studied excessive weight gain (BMI at 24 months ART greater than baseline and ≥25 kg/m2). Results The median BMI increase in DTG-based patients was 1.09 (IQR:-0.28,3.28) kg/m2 compared to 0.20 (IQR:-0.85,2.18) kg/m2 in EFV-based patients (p value = 0.001). DTG-based ART predicted excessive weight gain (aOR 2.61;95% CI:1.39–4.93). Conclusion Practitioners should consider DTG-based regimens as one of the risk factors for overweight/obesity.

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