Alkyl halides as both hydride and alkyl sources in catalytic regioselective reductive olefin hydroalkylation

Abstract

Methods that regioselectively install a functionalized alkyl unit at the 2-position of a terminal unactivated C=C bond are scarce. Here, the authors report a Markovnikov-selective hydroalkylation of unactivated amide-tethered alkenes catalyzed by nickel in conjunction with a stoichiometric reductant.