Communications Biology (Apr 2021)
Genomic landscape of extraordinary responses in metastatic breast cancer
- Sun Min Lim,
- Eunyoung Kim,
- Kyung Hae Jung,
- Sora Kim,
- Ja Seung Koo,
- Seung Il Kim,
- Seho Park,
- Hyung Seok Park,
- Byoung Woo Park,
- Young Up Cho,
- Ji Ye Kim,
- Soonmyung Paik,
- Nak-Jung Kwon,
- Gun Min Kim,
- Ji Hyoung Kim,
- Min Hwan Kim,
- Min Kyung Jeon,
- Sangwoo Kim,
- Joohyuk Sohn
Affiliations
- Sun Min Lim
- Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine
- Eunyoung Kim
- Department of Biomedical Systems Informatics, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine
- Kyung Hae Jung
- Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine
- Sora Kim
- Department of Biomedical Systems Informatics, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine
- Ja Seung Koo
- Department of Pathology, Yonsei University College of Medicine
- Seung Il Kim
- Department of General Surgery, Yonsei University College of Medicine
- Seho Park
- Department of General Surgery, Yonsei University College of Medicine
- Hyung Seok Park
- Department of General Surgery, Yonsei University College of Medicine
- Byoung Woo Park
- Department of General Surgery, Yonsei University College of Medicine
- Young Up Cho
- Department of General Surgery, Yonsei University College of Medicine
- Ji Ye Kim
- Department of General Surgery, Yonsei University College of Medicine
- Soonmyung Paik
- Severance Biomedical Science Institute and Department of Medical Oncology, Yonsei University College of Medicine
- Nak-Jung Kwon
- Macrogen, Inc
- Gun Min Kim
- Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine
- Ji Hyoung Kim
- Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine
- Min Hwan Kim
- Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine
- Min Kyung Jeon
- Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine
- Sangwoo Kim
- Department of Biomedical Systems Informatics, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine
- Joohyuk Sohn
- Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine
- DOI
- https://doi.org/10.1038/s42003-021-01973-x
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 9
Abstract
Lim, Kim and Jung et al. report a whole-exome sequence analysis of 30 Korean patients showing extreme treatment responses for metastatic breast cancer. They find that compared to non-responders, extreme responders have fewer nonsynonymous mutations and copy number variants.
