Nature Communications (Aug 2020)
Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
- Roy Rabbie,
- Naser Ansari-Pour,
- Oliver Cast,
- Doreen Lau,
- Francis Scott,
- Sarah J. Welsh,
- Christine Parkinson,
- Leila Khoja,
- Luiza Moore,
- Mark Tullett,
- Kim Wong,
- Ingrid Ferreira,
- Julia M. Martínez Gómez,
- Mitchell Levesque,
- Ferdia A. Gallagher,
- Alejandro Jiménez-Sánchez,
- Laura Riva,
- Martin L. Miller,
- Kieren Allinson,
- Peter J. Campbell,
- Pippa Corrie,
- David C. Wedge,
- David J. Adams
Affiliations
- Roy Rabbie
- Experimental Cancer Genetics, The Wellcome Sanger Institute
- Naser Ansari-Pour
- Big Data Institute, Nuffield Department of Medicine, University of Oxford
- Oliver Cast
- Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre
- Doreen Lau
- Department of Radiology, School of Clinical Medicine, University of Cambridge
- Francis Scott
- Department of Radiology, School of Clinical Medicine, University of Cambridge
- Sarah J. Welsh
- Cambridge Cancer Centre, Cambridge University Hospitals NHS Foundation Trust
- Christine Parkinson
- Cambridge Cancer Centre, Cambridge University Hospitals NHS Foundation Trust
- Leila Khoja
- Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, Vincent Drive, University of Birmingham
- Luiza Moore
- The Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute
- Mark Tullett
- St Richard’s Hospital, Spitalfield Lane
- Kim Wong
- Experimental Cancer Genetics, The Wellcome Sanger Institute
- Ingrid Ferreira
- Experimental Cancer Genetics, The Wellcome Sanger Institute
- Julia M. Martínez Gómez
- Department of Dermatology, University of Zurich, University of Zurich Hospital
- Mitchell Levesque
- Department of Dermatology, University of Zurich, University of Zurich Hospital
- Ferdia A. Gallagher
- Department of Radiology, School of Clinical Medicine, University of Cambridge
- Alejandro Jiménez-Sánchez
- Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre
- Laura Riva
- Experimental Cancer Genetics, The Wellcome Sanger Institute
- Martin L. Miller
- Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre
- Kieren Allinson
- Department of Pathology, Cambridge University Hospitals NHS Foundation Trust
- Peter J. Campbell
- The Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute
- Pippa Corrie
- Cambridge Cancer Centre, Cambridge University Hospitals NHS Foundation Trust
- David C. Wedge
- Big Data Institute, Nuffield Department of Medicine, University of Oxford
- David J. Adams
- Experimental Cancer Genetics, The Wellcome Sanger Institute
- DOI
- https://doi.org/10.1038/s41467-020-18060-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Metastatic melanoma is associated with a poor prognosis and understanding the genetic features of metastases may enable better treatment strategies. Here, the authors analyse multiple metastases from individual patients finding high levels of heterogeneity in metastases from different organs.
